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TH potentiates the production of non-12α-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12α-OH BAs, including T(α/β)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11
